What is QTL Analysis ?
QTL analysis is a statistical method used to links two types of information – Phenotypic data (Trait measurements) and Genotypic data (Molecular marker) in an attempt to explain the genetic basis of variation in complex traits.
Different types of QTL Analysis
Epigenetic Regulation
- caQTL – Chromatin accessibility QTL
- mQTL – DNA methylation QTL
- hQTL – Histone modification QTL
Transcriptional Regulation
- eQTL – gene expression QTL
- sQTL – alternative splicing QTL
Post transcriptional Regulation
- reQTL – RNA editing QTL
- cerQTL – Competing endogenous RNA expression
Translation Regulation
- riboQTL – Ribosome occupancy QTL
- pQTL – Protein expression QTL
Post translation Regulation
- metaQTL – Cell metabolisms QTL
References
Miles, C and Wayne, M. (2008). Quantitative trait locus (QTL) analysis. Nature Education 1(1): 208
Zhanye Zheng, Dandan Huang, Jianhua Wang, Ke Zhao and et al., (2020). QTLbase: an integrative resource for quantitative trait loci across multiple human molecular phenotypes, Nucleic Acids Research 48(D1): D983-D991
