BBPs- Bi-parental Populations
Bi-parental populations – derived from crosses between two inbreds lines. Standard design for genetic mapping.
- Relative simplicity of their construction
- High power to detect QTL because all allele frequencies are typically close to the optimal value of 50%
- Low rate of linkage disequilibrium decay within chromosomes – means only one or two recombinants per chromosome arm, hence only a few hundred genotyped markers are needed to map QTL.
- Lack of precision mapping due to limited effective recombination.
- Low genetic diversity, due to choice two founder parents lines – limit the number of QTL can be identified.
MPPs- Multi-parental Populations
Multi-parental populations- derived from crossing between many parents. Two popular MPP design –
- NAM-Nested Association mapping – constructed by series of crosses between a recurrent founder line and a number of alternative founders.
- MAGIC – Multi-parent advanced generations inter-cross – several founders are inter-crosses over multiple generation. Simple funnel breeding design.
- High mapping power and resolution
- Greater genetic diversity
- Minimal population structure.
- Long term durability
Scott, M.F., Ladejobi, O., Amer, S. et al. Multi-parent populations in crops: a toolbox integrating genomics and genetic mapping with breeding. Heredity (2020). https://doi.org/10.1038/s41437-020-0336-6