Marker, Mapping population, Application of markers in plant breeding.

Super dads or Surrogate Sires

  • Post category:Genomics

Super dads or Surrogate sires' are developed to broadcast desirable traits rapidly among the population of animals.  Drawbacks: Artificial Insemination       Practically artificial insemination in cow with sperm collected from elite bulls, has yielded cows that produces four times more milk. But hard to track down cows at the right stage of their reproductive cycle, in case of pigs it doesn't work well because sperm often die in…

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Different types of QTL analysis

  • Post category:Genomics

What is QTL Analysis ? QTL analysis is a statistical method used to links two types of information - Phenotypic data (Trait measurements) and Genotypic data (Molecular marker) in an attempt to explain the genetic basis of variation in complex traits.   Different types of QTL Analysis Epigenetic Regulation  caQTL - Chromatin accessibility QTL  mQTL - DNA methylation QTL  hQTL - Histone modification QTL  Transcriptional Regulation  eQTL - gene expression QTL  sQTL -…

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1000 Genome Project

  • Post category:Genomics

Human Genome Project It showed the importance  and the presence of genetic difference exists between individuals.  1000 Genome Project It measure those genetic difference, thereby helping medical researcher understand the role of genetic variation in health and illness.  About 1000-Genome Project It was also called as 1KGP was launched in January, 2008 and completed on 2015 funded by the Wellcome Trust under International Genome Sample Resource.  Research Institutes involved in this project…

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QTL Mapping

  • Post category:Genomics

What is QTL? Number of agronomically important traits - yield, quality, maturity, resistance to biotic and abiotic stress are the results of the interaction of number of gene loci called Quantitative Trait Loci,  display a large continuous range of variations forming a Normal bell shaped curve., hence can't be fitted to simple Mendelian ratio.   Principal of Mapping of QTLs Associate QTLs with molecular markers in their common inheritance and to…

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Difference between BPPs and MPPs

  • Post category:Genomics

BBPs- Bi-parental Populations Bi-parental populations - derived from crosses between two inbreds lines. Standard design for genetic mapping. Advantages Relative simplicity of their constructionHigh power to detect QTL because all allele frequencies are typically close to the optimal value of 50% Low rate of linkage disequilibrium decay within chromosomes - means only one or two recombinants per chromosome arm, hence only a few hundred genotyped markers are needed to map QTL. Disadvantage Lack of precision…

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